Medizinische Universität Graz - Research portal
Selected Publication:
Höfler, H; Ruhri, C; Pütz, B; Wirnsberger, G; Hauser, H.
Oncogene expression in endocrine pancreatic tumors.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1988; 55(6):355-361
Doi: 10.1007/BF02896594
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- Co-authors Med Uni Graz
- Hauser Hubert
- Wirnsberger Gerhard
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- Abstract:
- The mRNA expression of the (proto)oncogenes Ha-ras, Ki-ras, fos, c-myc, N-myc, and sis was studied in five pancreatic endocrine tumors and two non-neoplastic pancreatic tissues. Compared with non-tumorous pancreatic tissue, Ha-ras and Ki-ras mRNA was overexpressed up to 42-fold in all the tumors; metastasizing tumors showed 2-6 times higher Ha-ras mRNA levels than benign neoplasias. In contrast, c-myc mRNA levels were higher in normal tissue than n tumors and fos mRNA levels did not differ significantly between tumors and normal tissue. The activities of Ki-ras, fos and c-myc mRNA expression did not correlate with any of the histological or biological properties of the tumors, nor with the clinical course of disease. Our results, although based on a limited number of cases, suggest tha Ha-ras and Ki-ras mRNA overexpression is associated with the development of pancreatic endocrine tumors. The measurement of Ha-ras mRNA levels may contribute to the assessment of tumor prognosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Female -
- Gene Expression Regulation -
- Humans -
- Male -
- Middle Aged -
- Nucleic Acid Hybridization -
- Oncogenes -
- Pancreatic Neoplasms - genetics
- Proto-Oncogenes - genetics
- RNA Probes - genetics
- RNA, Messenger - genetics