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SHR Neuro Cancer Cardio Lipid Metab Microb
Stacher, E; Beham-Schmid, C; Terpe, HJ; Simiantonaki, N; Popper, HH.
Pulmonary histiocytic sarcoma mimicking pulmonary Langerhans cell histiocytosis in a young adult presenting with spontaneous pneumothorax: a potential diagnostic pitfall.
Virchows Arch. 2009; 455(2):187-190
Doi: 10.1007/s00428-009-0801-3
(- Case Report)
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- Leading authors Med Uni Graz
- Stacher-Priehse Elvira
- Co-authors Med Uni Graz
- Beham-Schmid Christine
- Popper Helmuth
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- Abstract:
- We present a case of a histiocytic sarcoma incidentally detected in peripheral lung tissue resected for a spontaneous pneumothorax. Furthermore, we discuss the practical approach to pulmonary Langerhans cell histiocytosis, the main differential diagnosis of this lesion in the lung, based on morphological and immunohistochemical features. A 23-year-old male patient presented with recurrent pneumothoraces. The pulmonary tissue showed a single round granuloma-like lesion measuring 4 mm in diameter in close neighbourhood to a bronchial wall. The granuloma consisted of histiocytic cells with enlarged pale nuclei, plasma cells, lymphocytes and scanty eosinophilic granulocytes giving the impression of a granuloma of pulmonary Langerhans cell histiocytosis on haematoxylin and eosin (H&E) stains. Immunohistochemically, the histiocytic cells were negative for CD1a and S-100. They were positive for CD68, HLA-DR, CD14, CD4, CD11c, CD45LCA and lysozyme. MIB1 (Ki67) showed a nuclear staining of approximately 10% of the histiocytic cells. In summary, these findings were in keeping with a histiocytic sarcoma, a rare haematopoetic neoplasm. By demonstrating this particular case, we emphasise the importance of proving the diagnosis of pulmonary Langerhans cell histiocytosis by means of immunohistochemistry. In case of a negative CD1a reaction in a histiocytic lesion, further immunohistochemical studies have to be performed in order not to misdiagnose a malignant haematopoetic lesion.
- Find related publications in this database (using NLM MeSH Indexing)
- Diagnosis, Differential -
- Histiocytic Sarcoma - complications
- Histiocytosis, Langerhans-Cell - diagnosis
- Humans -
- Lung Neoplasms - complications
- Male -
- Pneumothorax - diagnosis
- Young Adult -
- Find related publications in this database (Keywords)
- Histiocytic sarcoma
- Lung
- Immunohistochemistry
- Pulmonary Langerhans cell histiocytosis
- Pneumothorax