Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schröder, O; Schrott, M; Blumenstein, I; Jahnel, J; Dignass, AU; Stein, J.
A study for the evaluation of safety and tolerability of intravenous high-dose iron sucrose in patients with iron deficiency anemia due to gastrointestinal bleeding.
Z Gastroenterol. 2004; 42(8):663-667
Doi: 10.1055/s-2004-813106
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Jahnel Jörg
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- Abstract:
- INTRODUCTION: The provision of adequate iron to support erythropoiesis in iron deficient patients is a time-consuming process which may present compliance problems for patients in the outpatient setting. The aim of the present study was to evaluate the safety and tolerability of intravenous high-dose iron sucrose therapy specifically in patients with iron deficiency anemia (IDA) due to gastrointestinal blood loss. METHODS: A single dose of iron sucrose of 7 mg iron/kg body weight (not exceeding 500 mg) was infused over 3.5 hours in 31 consecutive patients with IDA due to gastrointestinal blood loss. Safety and tolerability of the therapy was assessed by the occurrence of adverse events under therapy and up to one week after completion of the study. Further examinations comprised vital parameters, ECG, and clinical chemistry including iron indices. RESULTS: A total of 14 adverse events were observed in 10 patients, of which two adverse events in two patients were considered as being definitely related to drug administration. None of the patients had to be withdrawn from therapy. Significant changes in vital parameters and ECG during therapy and follow-up were not observed and clinical chemistry remained unchanged. DISCUSSION: A single intravenous high-dose iron sucrose therapy in patients with IDA due to gastrointestinal blood loss appears to be safe and therefore is a therapeutic option which may save time and improve patient compliance.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Anaphylaxis - chemically induced
- Anemia, Iron-Deficiency - diagnosis Anemia, Iron-Deficiency - drug therapy Anemia, Iron-Deficiency - etiology
- Dose-Response Relationship, Drug -
- Drug Tolerance -
- Edema - chemically induced
- Female -
- Ferric Compounds - administration and dosage Ferric Compounds - adverse effects
- Gastrointestinal Hemorrhage - complications Gastrointestinal Hemorrhage - diagnosis Gastrointestinal Hemorrhage - drug therapy
- Humans -
- Infusions, Intravenous -
- Male -
- Middle Aged -
- Nausea - chemically induced
- Thrombophlebitis - chemically induced
- Treatment Outcome -
- Urticaria - chemically induced
- Find related publications in this database (Keywords)
- anemia
- inflammatory bowel disease
- intravenous iron infusion
- iron sucrose
- gastrointestinal blood loss