Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reiterer, F; Schenkeli, R; Kurz, R; Haidmayer, R.
Effect of aminophylline therapy in mature infants with sleep apnea syndrome
MONATSSCHR KINDERHEILK. 1988; 136(7): 368-371.
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Reiterer Friedrich
- Co-Autor*innen der Med Uni Graz
- Haidmayer Reinhard
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- Abstract:
- Pneumograms of 33 fullterm infants (age 1-16 weeks) with idiopathic sleep apnea syndrome (SAS), treated with aminophyllin administered orally, were compared with pneumograms of 12 age-matched infants without aminophyllin treatment. In a one hour oxycardiorespirography (OCRG) all infants had pneumogram abnormalities defined as apneas greater than or equal to 15 s, greater than or equal to 3 apneas lasting 10 s, MA-value (mean duration of all apneas during sleep time) greater than or equal to 7 s/min, and greater than or equal to 3 episodes of periodic breathing. The diagnosis of an SAS, discussed as a possible risk factor of SIDS, was made in general in the presence of clinical symptoms such as apneas, cyanosis during sleep, poorly coordinated sucking, swallowing and respiration, and gastro-esophageal reflux (GER) in combination with an abnormal pneumogram. Of the 33 infants 12 with a history of an SIDS sibling were clinically asymptomatic. We found that after one week of aminophyllin treatment in 88% the pneumograms were normal. The mean plasma concentration of aminophyllin at this time was 8.3 micrograms/ml (range 4-19 micrograms/ml). All abnormalities showed a statistically significant reduction. In the infants without aminophyllin the pneumogram was still abnormal and no abnormality was significantly reduced. After at least 6 weeks we discontinued aminophyllin and one week later we monitored the OCRG. In 83% of the infants we found a normal pneumogram and compared to the initial pneumogram there was again a statistically significant difference.(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Aminophylline - pharmacokinetics
- Drug Administration Schedule - pharmacokinetics
- Humans - pharmacokinetics
- Infant - pharmacokinetics
- Infant, Newborn - pharmacokinetics
- Sleep Apnea Syndromes - drug therapy
- Sudden Infant Death - prevention and control