Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wehr, E; Möller, R; Horejsi, R; Giuliani, A; Kopera, D; Schweighofer, N; Groselj-Strele, A; Pieber, TR; Obermayer-Pietsch, B.
Subcutaneous adipose tissue topography and metabolic disturbances in polycystic ovary syndrome.
Wien Klin Wochenschr. 2009; 121(7-8):262-269
Doi: 10.1007/s00508-009-1162-2
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- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Co-Autor*innen der Med Uni Graz
- Giuliani Albrecht
- Groselj-Strele Andrea
- Horejsi Renate
- Kopera Daisy
- Möller Reinhard
- Obermayer-Pietsch Barbara
- Pieber Thomas
- Schweighofer Natascha
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- Abstract:
- Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. Central obesity plays a major role in the pathophysiology of PCOS. However, there is little information on the impact of subcutaneous adipose tissue (SAT) on metabolic disturbances in PCOS. The aim of this study was to investigate whether SAT topography influences insulin resistance, impaired glucose tolerance and metabolic parameters in women with PCOS. 36 women aged 16-41 years with PCOS and 87 healthy women aged 20-34 years were examined using lipometry, metabolic and hormonal measurements, oral glucose tolerance tests, hirsutism scores, and questionnaires. The homeostasis model assessment (HOMA) index was used for determination of insulin resistance. SAT measurement points on the trunk showed significant positive correlation with the HOMA index. A negative correlation between calf SAT and the HOMA index was seen. Multiple regression analysis detected a positive association between the HOMA index and lower-abdomen SAT and upper-back SAT, whereas hip SAT showed a negative association with the HOMA index. In overweight/obese patients with PCOS, lower-abdomen and upper-back SAT showed significant positive correlations with insulin resistance. There was no correlation of SAT topography with insulin resistance in lean women with PCOS. Compared with PCOS women with normal glucose tolerance, patients with glucose intolerance had significantly increased trunk obesity and decreased leg fat. Increased SAT layers on the trunk were related to an unfavorable serum lipid profile, whereas increased leg fat correlated positively with HDL cholesterol. Increased SAT layers on the trunk are associated with insulin resistance, impaired glucose tolerance and an unfavorable lipid profile in women suffering from PCOS. Increased thickness of leg SAT emerges as being protective against metabolic disturbances in PCOS.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Blood Glucose - metabolism
- Body Composition - physiology
- Body Fat Distribution -
- Body Mass Index -
- Female -
- Humans -
- Insulin Resistance - physiology
- Lipids - blood
- Metabolic Syndrome - diagnosis
- Metabolic Syndrome - physiopathology
- Polycystic Ovary Syndrome - diagnosis
- Polycystic Ovary Syndrome - physiopathology
- Risk Factors -
- Skinfold Thickness -
- Statistics as Topic -
- Subcutaneous Fat, Abdominal - physiopathology
- Waist-Hip Ratio -
- Young Adult -
- Find related publications in this database (Keywords)
- Polycystic ovary syndrome
- subcutaneous adipose tissue topography
- insulin resistance
- impaired glucose tolerance
- central obesity