Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Khalil, M; Enzinger, C; Langkammer, C; Tscherner, M; Wallner-Blazek, M; Jehna, M; Ropele, S; Fuchs, S; Fazekas, F.
Quantitative assessment of brain iron by R(2)* relaxometry in patients with clinically isolated syndrome and relapsing-remitting multiple sclerosis.
Mult Scler. 2009; 15(9): 1048-1054.
Doi: 10.1177/1352458509106609
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- Führende Autor*innen der Med Uni Graz
- Fazekas Franz
- Khalil Michael
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fuchs Siegrid
- Jehna Margit
- Langkammer Christian
- Ropele Stefan
- Tscherner Maria
- Wallner-Blazek Mirja
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- Abstract:
- Background Increased iron deposition has been implicated in the pathophysiology of multiple sclerosis (MS), based on visual analysis of signal reduction on T-2-weighted images. R-2* relaxometry allows to assess brain iron accumulation quantitatively. Objective To investigate regional brain iron deposition in patients with a clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS) and its associations with demographical, clinical, and conventional magnetic resonance imaging (MRI) parameters. Methods We studied 69 patients (CIS, n = 32; RRMS, n = 37) with 3T MRI and analyzed regional R-2* relaxation rates and their correlations with age, disease duration, disability, T-2 lesion load, and normalized brain volumes. Results Basal ganglia R-2* relaxation rates increased in parallel with age (r = 0.3-0.6; P < 0.01) and were significantly higher in RRMS than in CIS (P < 0.05). Using multivariate linear regression analysis, the rate of putaminal iron deposition was independently predicted by the patients' age, disease duration, and gray matter atrophy. Conclusions Quantitative assessment by R-2* relaxometry suggests increased iron deposition in the basal ganglia of MS patients, which is associated with disease duration and brain atrophy. This technique together with long-term follow-up thus appears suited to clarify whether regional iron accumulation contributes to MS morbidity or merely reflects an epiphenomenon. Multiple Sclerosis 2009; 15: 1048-1054. http://msj.sagepub.com
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Atrophy -
- Basal Ganglia - metabolism Basal Ganglia - pathology
- Brain Mapping - methods
- Brain Stem - metabolism Brain Stem - pathology
- Demyelinating Diseases - metabolism Demyelinating Diseases - pathology
- Female -
- Hippocampus - metabolism Hippocampus - pathology
- Humans -
- Iron - metabolism
- Magnetic Resonance Imaging - methods
- Male -
- Multiple Sclerosis, Relapsing-Remitting - metabolism Multiple Sclerosis, Relapsing-Remitting - pathology
- Thalamus - metabolism Thalamus - pathology
- Young Adult -
- Find related publications in this database (Keywords)
- 3T MRI
- brain atrophy
- deep gray matter
- iron deposition
- multiple sclerosis
- R-2* mapping