Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Urban, C; Schwingshandl, J; Slavc, I; Gamillscheg, A; Hauer, C; Schmid, G; Kaulfersch, W; Borkenstein, M.
Endocrine function after bone marrow transplantation without the use of preparative total body irradiation.
Bone Marrow Transplant. 1988; 3(4):291-296
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Führende Autor*innen der Med Uni Graz: Urban Ernst-Christian
Co-Autor*innen der Med Uni Graz: Borkenstein Helmuth Martin; Gamillscheg Andreas; Hauer Almuthe
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Abstract:: Ten children who underwent allogeneic (n = 5) or autologous (n = 5) bone marrow transplantation (BMT) for chronic myelogenous leukaemia (n = 2), acute lymphoblastic leukaemia (n = 1), acute myelogenous leukaemia (n = 2), severe aplastic anaemia (n = 2), malignant histiocytosis (n = 1), neuroblastoma (n = 1) and teratoma (n = 1) were assessed for endocrinological function. Transplant preparative regimens consisted of high-dose cyclophosphamide, high-dose cyclophosphamide in combination with high-dose busulphan, high-dose melphalan as well as BACT (BCNU, cytarabine, cyclophosphamide and 6-thioguanine) chemotherapy. None of the patients received total body irradiation (TBI). Median survival following BMT was 37 months (range 7-115). Growth hormone deficiency was present in only one patient; none of the patients had abnormal thyroid or adrenocortical function. This is in contrast to previous reports in which growth hormone deficiency and abnormal thyroid and adrenocortical function occurred in a much higher percentage of patients after BMT conditioned with TBI.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adrenal Cortex Function Tests -; Adult -; Bone Marrow Transplantation -; Child -; Child, Preschool -; Endocrine Glands - physiology; Female - physiology; Growth Hormone - blood; Humans - blood; Male - blood; Ovarian Function Tests - blood; Puberty - blood; Testis - physiology; Thyroid Function Tests - physiology; Whole-Body Irradiation - physiology