Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sourij, H; Schmoelzer, I; Kettler-Schmut, E; Eder, M; Pressl, H; Decampo, A; Wascher, TC.
Efficacy of a continuous GLP-1 infusion compared with a structured insulin infusion protocol to reach normoglycemia in nonfasted type 2 diabetic patients: a clinical pilot trial.
Diabetes Care. 2009; 32(9): 1669-1671.
Doi: 10.2337/dc09-0475
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- Führende Autor*innen der Med Uni Graz
- Sourij Harald
- Wascher Thomas
- Co-Autor*innen der Med Uni Graz
- DeCampo Antonella
- Kettler-Schmut Eva
- Pressl Helga
- Steinberger Michaela
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- Abstract:
- OBJECTIVE - Continuously administered insulin is limited by the need for frequent blood glucose measurements, dose adjustments, and risk of hypoglycemia. Regimens based on glucagon-like peptide 1 (GLP-1) could represent a less complicated treatment alternative. This alternative might be advantageous in hyperglycemic patients hospitalized for acute critical illnesses, who benefit from near normoglycemic control. RESEARCH DESIGN AND METHODS - in a prospective open randomized. crossover trial, we investigated eight clinically stable type 2 diabetic patients during intravenous insulin or GLP-1 regimens to normalize blood glucose after a standardized breakfast. RESULTS - The time to reach a plasma glucose below 11.5 mg/dl was significantly shorter during GLP-1 administration (252 +/- 51 vs. 321 +/- 43 min, P < 0.01). Maximum glycemia (312 +/- 51 vs. 254 +/- 48 mg/dl, P < 0.01) and glycemia after 2 h (271 +/- 51 vs. 168 +/- 48 mg/dl, P = 0.012) and after 4 h (155 51 vs. 116 27 mg/dl, P = 0.02) were significantly lower during GLP-1 administration. CONCLUSIONS - GLP-1 infusion is superior to an established insulin infusion regimen with regard to effectiveness and practicability.
- Find related publications in this database (using NLM MeSH Indexing)
- Cross-Over Studies -
- Diabetes Mellitus, Type 2 - drug therapy
- Female -
- Glucagon-Like Peptide 1 - administration and dosage
- Humans -
- Hypoglycemic Agents - administration and dosage
- Incretins - administration and dosage
- Insulin - administration and dosage
- Male -
- Middle Aged -