Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hammer, HF.
Reflux-associated laryngitis and laryngopharyngeal reflux: a gastroenterologist's point of view.
DIGEST DIS. 2009; 27(1): 14-17.
Doi: 10.1159/000210098
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hammer Heinz
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- Abstract:
- Laryngopharyngeal reflux of liquid and gaseous gastric contents should be considered in every patient with unexplained hoarseness. Pathophysiology and treatment of reflux-associated laryngitis are different from those of reflux esophagitis and therefore remain an unsolved puzzle. The laryngeal mucosa is considerably more sensitive to acid and pepsin than the mucosa of the esophagogastric junction. Therefore definitions of acid and nonacid reflux used for gastroesophageal reflux disease may not be helpful for explaining pathophysiologic mechanisms in the larynx or pharynx. A reflux symptom index and reflux finding score may be useful in helping to select the minority of patients who may benefit from acid-suppressive therapy; however, further research is needed. Further research is also needed to identify those patients who may require higher doses or prolonged duration of proton pump inhibitors or alternative treatments like prokinetics or alginate, or those patients who may benefit from surgical treatment of gastroesophageal reflux. Since symptoms of laryngopharyngeal reflux may predict esophageal adenocarcinoma, every patient with laryngopharyngeal reflux should have an upper gastrointestinal endoscopy, even if no classical symptoms of gastroesophageal reflux disease are present.
- Find related publications in this database (using NLM MeSH Indexing)
- Gastroesophageal Reflux - complications Gastroesophageal Reflux - diagnosis
- Gastrointestinal Agents - therapeutic use
- Hoarseness - etiology Hoarseness - pathology
- Humans -
- Hypopharynx - pathology
- Laryngeal Diseases - drug therapy Laryngeal Diseases - etiology Laryngeal Diseases - pathology
- Laryngeal Mucosa - pathology
- Laryngitis - drug therapy Laryngitis - etiology Laryngitis - pathology
- Laryngoscopy -
- Proton Pumps - antagonists and inhibitors
- Treatment Failure -
- Find related publications in this database (Keywords)
- Laryngitis
- Laryngopharyngeal reflux
- Gastroesophageal reflux
- Hoarseness
- Reflux symptom index