Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wölfler, A; Schauenstein, K; Liebmann, PM.
Lack of calmodulin antagonism of melatonin in T-lymphocyte activation.
Life Sci. 1998; 63(10):835-842
Doi: 10.1016/S0024-3205(98)00340-3
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Liebmann-Holzmann Peter
- Wölfler Albert
- Co-Autor*innen der Med Uni Graz
- Schauenstein Konrad
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Despite various reported effects of the pineal hormone melatonin on the immune system, its mechanism of action on immune cells is still unknown. Since melatonin has been suggested as a physiological antagonist to calmodulin in certain cell types, we investigated effects of melatonin on calmodulin-dependent IL-2 production and proliferation of activated T-lymphocytes. It was found, however, that, in contrast to the calmodulin antagonists trifluoperazine and W7, melatonin neither inhibited the IL-2 production of activated lymphoblastoid Jurkat T-cells nor decreased the mitogen response of peripheral blood mononuclear leukocytes. Preincubation of Jurkat cells with melatonin did not influence trifluoperazine effects on IL-2 production indicating that melatonin does not bind to the same sites of calmodulin as trifluoperazine, as has been postulated. In conclusion, these results did not give any evidence for a calmodulin antagonism of melatonin in T-lymphocyte activation. Thus, melatonin as a calmodulin antagonist appears not to be a universal phenomenon.
- Find related publications in this database (using NLM MeSH Indexing)
- Calcium-Calmodulin-Dependent Protein Kinases - antagonists and inhibitors
- Calmodulin - antagonists and inhibitors
- Dopamine Antagonists - pharmacology
- Enzyme Inhibitors - pharmacology
- Enzyme-Linked Immunosorbent Assay - pharmacology
- Humans - pharmacology
- Interleukin-1 - biosynthesis
- Ionomycin - pharmacology
- Ionophores - pharmacology
- Jurkat Cells - pharmacology
- Kinetics - pharmacology
- Lymphocyte Activation - drug effects
- Melatonin - antagonists and inhibitors
- Signal Transduction - drug effects
- Sulfonamides - pharmacology
- T-Lymphocytes - drug effects
- Trifluoperazine - pharmacology
- Find related publications in this database (Keywords)
- Melatonin
- Calmodulin
- IL-2 Production
- T-Lymphocyte Activation