Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Karàdi, I; Kostner, GM; Gries, A; Nimpf, J; Romics, L; Malle, E.
Lipoprotein (a) and plasminogen are immunochemically related.
Biochim Biophys Acta. 1988; 960(1):91-97
Doi: 10.1016/0005-2760(88)90013-6
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Gries Anna
- Kostner Gerhard
- Malle Ernst
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Earlier studies demonstrated that lipoprotein (a), a lipoprotein of high atherogenicity, possesses proteolytic activity. In this report, we provide evidence that the lipoprotein (a)-specific antigen, apoprotein (a) is immunochemically related to plasminogen. This was demonstrated by polyclonal antisera from rabbit, sheep and horse, and with three monoclonal antibodies from mouse. Using immunospecific adsorbers against lipoprotein (a), all plasminogen could be adsorbed from lipoprotein (a)-positive and apparently lipoprotein (a)-negative plasma. As an additional similarity to plasminogen, lipoprotein (a) binds selectively to lysine-Sepharose, but with a somewhat lower affinity. In an assay system for measuring the fibrinolytic activity challenged with streptokinase, lipoprotein (a) prolonged strikingly the fibrinolysis time under certain experimental conditions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Animals -
- Antibody Affinity -
- Apolipoproteins A - immunology
- Electrophoresis, Polyacrylamide Gel - immunology
- Epitopes - analysis
- Female - analysis
- Fibrinolysis - drug effects
- Horses - drug effects
- Humans - drug effects
- Lipoprotein(a) - drug effects
- Lipoproteins - immunology
- Male - immunology
- Mice - immunology
- Plasminogen - immunology
- Rabbits - immunology
- Sheep - immunology
- Streptokinase - antagonists and inhibitors