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Selected Publication:
Valenta, R; Almo, S; Ball, T; Dolecek, C; Steinberger, P; Laffer, S; Eibensteiner, P; Flicker, S; Vrtala, S; Spitzauer, S; Valent, P; Denepoux, S; Kraft, D; Banchereau, J; Lebecque, S.
The immunoglobulin E-allergen interaction: a target for therapy of type I allergic diseases.
Int Arch Allergy Immunol. 1998; 116(3):167-176
Doi: 10.1159/000023942
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- Co-authors Med Uni Graz
- Ball Tanja
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- Abstract:
- The interaction of immunoglobulin E and otherwise harmless antigens (allergens) leads in sensitized individuals through effector cell activation to the immediate induction of a cascade of inflammatory reactions, the hallmark of type I allergy. Recently, the molecular and structural characterization of allergens, specific IgE antibodies and their epitopes has made rapid progress. Here we discuss active and passive strategies for therapy of type I allergy, which are based on interfering with the IgE-allergen interaction.
- Find related publications in this database (using NLM MeSH Indexing)
- Allergens - chemistry Allergens - immunology
- Animals -
- Antigen-Antibody Reactions -
- Epitopes, B-Lymphocyte - immunology
- Humans -
- Hypersensitivity - immunology Hypersensitivity - therapy
- Immunoglobulin E - immunology
- Vaccination -
- Find related publications in this database (Keywords)
- type I allergy
- immunoglobulin E
- recombinant allergens
- blocking antibody
- immunotherapy