Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brunasso, AM; Massone, C.
Thrombocytopenia associated with the use of anti-tumor necrosis factor-alpha agents for psoriasis.
J Am Acad Dermatol. 2009; 60(5):781-785
Doi: 10.1016/j.jaad.2008.12.001
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Brunasso Vernetti Alexandra Maria
- Massone Cesare
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- Abstract:
- Thrombocytopenia has been reported to be associated with efalizumab therapy, but has only sporadically been reported with other anti-tumor necrosis factor alfa (TNF-alpha) agents. To describe the frequency of thrombocytopenia in a cohort of patients who underwent biological therapies for psoriasis. This was a retrospective observational study of 93 patients. One hundred eighteen courses of biological therapies were administered to 93 patients. Four of 67 patients who received anti-TNF-alpha agents developed drug-induced thrombocytopenia during treatment, compared with none of the 51 patients receiving efalizumab therapy. The platelet count recovered after suspension of anti-TNF-alpha agents in 3 patients and relapsed after re-exposure in two patients. The overall estimated frequency of thrombocytopenia in our cohort was 4.30% (95% confidence interval [CI], 0% to 6.2%). These findings should be validated in larger studies. Drug-induced thrombocytopenia is a potential side effect of anti-TNF-alpha agents. Immediate monitoring of platelet counts is recommended if autoimmunity is suspected.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Antibodies, Monoclonal - therapeutic use
- Arthritis, Psoriatic - drug therapy
- Female -
- Humans -
- Male -
- Middle Aged -
- Platelet Count -
- Psoriasis - drug therapy
- Retrospective Studies -
- Thrombocytopenia - chemically induced
- Tumor Necrosis Factor-alpha - antagonists & inhibitors
- Find related publications in this database (Keywords)
- adalimumab
- efalizumab
- etanercept
- infliximab
- psoriasis
- thrombocytopenia