Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kofler, B; Mueller, EE; Eder, W; Stanger, O; Maier, R; Weger, M; Haas, A; Winker, R; Schmut, O; Paulweber, B; Iglseder, B; Renner, W; Wiesbauer, M; Aigner, I; Santic, D; Zimmermann, FA; Mayr, JA; Sperl, W.
Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study.
BMC Med Genet. 2009; 10(8):35-35
Doi: 10.1186/1471-2350-10-35
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- Co-Autor*innen der Med Uni Graz
- Haas Anton
- Maier Richard
- Renner Wilfried
- Schmut Otto
- Weger Martin
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- Abstract:
- There is strong and consistent evidence that oxidative stress is crucially involved in the development of atherosclerotic vascular disease. Overproduction of reactive oxygen species (ROS) in mitochondria is an unifying mechanism that underlies micro- and macrovascular atherosclerotic disease. Given the central role of mitochondria in energy and ROS production, mitochondrial DNA (mtDNA) is an obvious candidate for genetic susceptibility studies on atherosclerotic processes. We therefore examined the association between mtDNA haplogroups and coronary artery disease (CAD) as well as diabetic retinopathy. This study of Middle European Caucasians included patients with angiographically documented CAD (n = 487), subjects with type 2 diabetes mellitus with (n = 149) or without (n = 78) diabetic retinopathy and control subjects without clinical manifestations of atherosclerotic disease (n = 1527). MtDNA haplotyping was performed using multiplex PCR and subsequent multiplex primer extension analysis for determination of the major European haplogroups. Haplogroup frequencies of patients were compared to those of control subjects without clinical manifestations of atherosclerotic disease. Haplogroup T was significantly more prevalent among patients with CAD than among control subjects (14.8% vs 8.3%; p = 0.002). In patients with type 2 diabetes, the presence of diabetic retinopathy was also significantly associated with a higher prevalence of haplogroup T (12.1% vs 5.1%; p = 0.046). Our data indicate that the mtDNA haplogroup T is associated with CAD and diabetic retinopathy in Middle European Caucasian populations.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Aged, 80 and over -
- Case-Control Studies -
- Coronary Artery Disease - genetics
- DNA, Mitochondrial - genetics
- Diabetic Retinopathy - genetics
- Female -
- Gene Frequency -
- Genetic Predisposition to Disease -
- Haplotypes -
- Humans -
- Male -
- Middle Aged -
- Odds Ratio -
- Polymorphism, Single Nucleotide -