Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Smolle, J; Soyer, HP; Juettner, FM; Torne, R; Stettner, H; Kerl, H.
HLA-DR-positive keratinocytes are associated with suppressor lymphocyte epidermotropism. A biomathematical study.
AMER J DERMATOPATHOL. 1988; 10(2): 128-132. Doi: 10.1097/00000372-198804000-00005
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Führende Autor*innen der Med Uni Graz: Smolle Josef
Co-Autor*innen der Med Uni Graz: Kerl Helmut; Smolle-Juettner Freyja-Maria; Soyer Hans Peter
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Abstract:: The expression of HLA-DR antigen on keratinocytes has recently been described as a frequent finding in various dermatologic disorders without restriction to a particular entity or a peculiar histologic reaction pattern, except for the association with a mononuclear dermal infiltrate. To determine the relationship of HLA-DR+ keratinocytes and T lymphocyte epidermotropism in human disease in vivo, 82 skin specimens were investigated by immunohistologic and stereologic methods and by two- and three-dimensional linear regression analysis. In randomly selected cases of various dermatoses, HLA-DR+ keratinocytes were associated with T lymphocyte epidermotropism. Furthermore, HLA-DR+ keratinocytes correlated particularly with the proportion of epidermotropic suppressor/cytotoxic cells. Our findings demonstrate that HLA-DR+ keratinocytes are associated with a particular pattern of epidermotropism, which may suggest an interaction of keratinocytes and T suppressor/cytotoxic cells in vivo.
Find related publications in this database (using NLM MeSH Indexing): Antibodies, Monoclonal -; Epidermis - cytology; HLA-DR Antigens - analysis; Humans - analysis; Immunoenzyme Techniques - analysis; Keratins - immunology; Models, Theoretical - immunology; Regression Analysis - immunology; Skin - immunology; Skin Diseases - immunology; T-Lymphocytes, Regulatory - immunology