Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schwarz, HP; Muntean, W; Watzke, H; Richter, B; Griffin, JH.
Low total protein S antigen but high protein S activity due to decreased C4b-binding protein in neonates.
Blood. 1988; 71(3):562-565
Doi: 10.1182/blood.V71.3.562.bloodjournal713562
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- Co-Autor*innen der Med Uni Graz
- Muntean Eugen
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- Abstract:
- Protein S, a vitamin K-dependent cofactor for activated protein C, exists in normal adult plasma in a free anticoagulantly active form and in an inactive form complexed to C4b-binding protein. Immunologic and functional levels of protein S and C4b-binding protein in plasma were determined for 20 newborn infants and compared with adult normal pooled plasma. Total protein S antigen levels averaged 23%, similar to other vitamin K-dependent plasma proteins. However, the protein S anticoagulant activity was 74% of that of adult normal plasma. This apparent discrepancy of activity to antigen was shown to be due to low or undetectable levels of C4b-binding protein, which results in the presence of most if not all of protein S in its free and active form. The relatively high level of anticoagulantly active protein S in infants may enhance the potential of the protein C pathway, thereby minimizing risks of venous thrombosis in this group.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens - analysis
- Carrier Proteins - metabolism
- Complement Inactivator Proteins - metabolism
- Glycoproteins - immunology
- Humans - immunology
- Immunoelectrophoresis - immunology
- Immunologic Techniques - immunology
- Infant, Newborn - immunology
- Protein S - immunology