Medizinische Universität Graz - Research portal
Selected Publication:
Klimpfinger, M; Ruhri, C; Pütz, B; Pfragner, R; Wirnsberger, G; Höfler, H.
Oncogene expression in a medullary thyroid carcinoma.
VIRCHOWS ARCH B CELL PATH. 1988; 54(4): 256-259.
Doi: 10.1007/BF02899220
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Pfragner Roswitha
- Wirnsberger Gerhard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- We report the expression of Ha-ras, fos, c-myc and N-myc mRNA in a human medullary carcinoma of the thyroid gland, both in primary tumor and lymph node metastasis, as demonstrated by in situ hybridization and Northern blot analysis. A significant difference in the oncogene expression in the primary tumor and the metastasis was not observed. Tumor tissue revealed a significant overexpression of Ha-ras, c-myc and N-myc mRNA as compared to the normal thyroid gland. The amount of fos mRNA expression in non tumorous thyroid gland did not significantly differ from tumor tissue, sis, fms and abl mRNA expression was not detectable in tumor tissue and non tumorous thyroid gland. We conclude, that the (over)expression of the oncogenes Ha-ras, c-myc and N-myc may be associated with initiation and progression of medullary thyroid carcinoma. Similar studies on additional cases of human medullary thyroid carcinoma will be necessary to reveal further information.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Autoradiography -
- Carcinoma - analysis
- Female - analysis
- Humans - analysis
- Immunoassay - analysis
- Lymphatic Metastasis - analysis
- Male - analysis
- Middle Aged - analysis
- Nucleic Acid Hybridization - analysis
- Oncogenes - analysis
- RNA, Messenger - analysis
- RNA, Neoplasm - analysis
- Thyroid Neoplasms - analysis