Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Painsipp, E; Sperk, G; Herzog, H; Holzer, P.
Delayed stress-induced differences in locomotor and depression-related behaviour in female neuropeptide-Y Y1 receptor knockout mice.
J Psychopharmacol. 2010; 24(10):1541-1549
Doi: 10.1177/0269881109104851
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Singewald Evelin
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- Abstract:
- Neuropeptide-Y acting through Y1 receptors reduces anxiety and stress sensitivity in rodents. In Y1 receptor knockout (Y1⁻/⁻) mice, however, anxiety-related behaviour is altered only in a context-dependent manner. Here, we investigated whether stress causes a delayed change in the emotional-affective behaviour of female Y1⁻/⁻ mice. Locomotor and anxiety-related behaviour was assessed with the elevated plus-maze (EPM) test and depression-like behaviour with the forced swim test (FST). These behavioural tests were also used as experimental stress paradigms. Locomotion and anxiety-like behaviour did not differ between naïve control and Y1⁻/⁻ mice. One week after the FST, locomotion was reduced in control animals but unchanged in Y1⁻/⁻ mice, whereas anxiety-like behaviour remained unaltered in both genotypes. Depression-like behaviour (immobility) was identical in naïve control and Y1⁻/⁻ mice but, 1 week after the EPM test, was attenuated in Y1⁻/⁻ mice relative to control animals. Our data show that naïve female Y1⁻/⁻ mice do not grossly differ from female control animals in their locomotor and depression-like behaviour. Exposure to the stress associated with behavioural testing, however, leads to delayed genotype-dependent differences in locomotion and depression-like behaviour. These findings attest to a role of Y1 receptor signalling in the control of stress coping and/or adaptation.
- Find related publications in this database (using NLM MeSH Indexing)
- Analgesia -
- Animals -
- Anxiety -
- Behavior, Animal -
- Corticosterone - blood
- Depression - blood
- Female -
- Mice -
- Mice, 129 Strain -
- Mice, Inbred C57BL -
- Mice, Knockout -
- Motor Activity -
- Neuropeptide Y - physiology
- Pain Measurement -
- Reaction Time -
- Receptors, Neuropeptide Y - genetics
- Signal Transduction -
- Stress, Physiological -
- Stress, Psychological - blood
- Time Factors -
- Find related publications in this database (Keywords)
- anxiety-like behaviour
- depression-like behaviour
- locomotor activity
- neuropeptide-Y
- neuropeptide-Y Y1 receptors
- stress sensitivity
- thermal nociception