Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wildburger, R; Mrakovcic, L; Stroser, M; Andrisic, L; Sunjic, SB; Zarkovic, K; Zarkovic, N.
Lipid Peroxidation and Age-Associated Diseases-Cause or Consequence?: Review
TURK KLIN TIP BILIM DERG. 2009; 29(1): 189-193.
Web of Science
- Leading authors Med Uni Graz
- Wildburger Renate
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- Abstract:
- Aging is progressive and deleterious process in many aspects common to all living organisms. In humans, development of various diseases, such as neurodegenerative diseases, cardiovascular diseases, some forms of cancer, metabolic disorders, diabetes, certain autoimmune and bone diseases, is proportional to aging. Therefore, it seems that excess in production of reactive oxygen species causing oxidative stress and lipid peroxidatioin plays important role in aging, homeostasis and initiation of age-associated diseases. Hence, oxidative stress and lipid peroxidation could be considered both as causative for particular age-associated diseases as well as cofactors of aging. However, constant but moderate oxidative stress might have beneficial impact upon increment of antioxidative capacities thus preventing initiation of age-associated diseases and extending aging.
- Find related publications in this database (Keywords)
- Aging
- oxidative stress
- lipid peroxidation
- 4-hydroxynonenal