Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Liegl, B; Hornick, JL; Lazar, AJF.
Contemporary pathology of gastrointestinal stromal tumors.
HEMATOL ONCOL CLIN N AMER. 2009; 23(1): 49-68.
Doi: 10.1016/j.hoc.2008.12.002
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Liegl-Atzwanger Bernadette
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- Abstract:
- Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. The vast majority of GISTs harbor a KIT or PDGFRA mutation and express KIT by immunohistochemistry. However, KIT-negative tumors and tumors showing unusual morphologic features can cause major diagnostic problems. The ability to inhibit the active KIT or PDGFRA kinase with tyrosine kinase inhibitors and alternative drugs demands more than ever accurate tumor classification and risk assessment. This article focuses on the pathology of GIST, including unusual variants and morphologic changes resulting from treatment. Parameters for risk assessment, potentially helpful new immunohistochemical markers, differential diagnosis, and the application of molecular classification schemes are discussed.
- Find related publications in this database (using NLM MeSH Indexing)
- Gastrointestinal Stromal Tumors - classification
- Humans -
- Immunohistochemistry -
- Molecular Diagnostic Techniques -
- Risk Assessment -
- Tumor Markers, Biological -
- Find related publications in this database (Keywords)
- Gastrointestinal stromal tumor
- KIT
- Pathology
- Risk assessment
- Molecular prognosis
- Targeted therapy
- Biomarkers
- Post-treatment changes