Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kofler, H; Aberer, W; Deibl, M; Hawranek, T; Klein, G; Reider, N; Fellner, N.
Diamine oxidase (DAO) serum activity: not a useful marker for diagnosis of histamine intolerance
ALLERGOLOGIE. 2009; 32(3): 105-109.
Doi: 10.5414/ALP32105
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- Co-Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- Although exact numbers on the prevalence of histamine intolerance are lacking, it seems to be on a rise during the last years. The estimated prevalence in the population is 3%. This is particularly true for middle-aged female patients. A deficiency of I of the histamine metabolizing enzymes, diamine oxidase (DAO) has been postulated as the main causal factor. Recently, a commercial radioimmunoassay for determination of DAO activity has been launched. To evaluate the clinical impact of this assay for the diagnosis of histamine intolerance, we performed a prospective, multicentre study in 207 adult patients. In 77 patients, a diagnosis of histamine intolerance was made based on clinical criteria, in 67 a diagnosis "in question", and 61 healthy patients without anamnestic evidence for histamine intolerance served as a control. Interestingly, no correlation between diamine oxidase serum levels and clinical status could be found in any of the 3 groups. We, therefore, recommend further investigations, before determination of DAO serum activity should be used as a screening tool for the diagnosis of histamine intolerance.
- Find related publications in this database (Keywords)
- diamine oxidase
- DAO
- histamine intolerance
- histamine metabolism