Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Massone, C; Horn, M; Kerl, H; Ambros-Rudolph, CM; Giovanna Brunasso, AM; Cerroni, L.
Foreign body granuloma due to Matridex injection for cosmetic purposes.
Am J Dermatopathol. 2009; 31(2):197-199
Doi: 10.1097/DAD.0b013e318194816d
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Massone Cesare
- Co-Autor*innen der Med Uni Graz
- Ambros-Rudolph Christina
- Brunasso Vernetti Alexandra Maria
- Horn Michael
- Kerl Helmut
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- Abstract:
- A new resorbable filler, Matridex, became commercially available during the last years with scarce evidence regarding side effects. A 43-year-old woman complained of multiple, painful, reddish, nonulcerated, hard nodules on both cheeks and periocular regions. Four weeks before, she had been injected by a general practitioner with Matridex for aesthetic purposes to correct wrinkles in the same areas of the nodular eruption. Histopathology showed a diffuse suppurative granulomatous reaction with the presence of multinucleate giant cells and many neutrophils involving the entire dermis. No areas of caseation were observed. The inflammatory granulomatous reaction surrounded 2 different types of nonpolarizing, bluish, exogenous material: one arranged in filamentous structures and the second composed by large spherical particles. All nodules were incised and drained; the patient received systemic antibiotic treatment for 2 consecutive weeks. The nodules progressively regressed and almost complete resolution was seen after 6 months. Matridex is a new resorbable filler constituted by a mixture of nonanimal-stabilized hyaluronic acid (HA), cross-linked HA, and dextranomer microspheres. Foreign body reactions have been described in association with other HA fillers, but a granulomatous reaction after the injection of Matridex has not been reported yet. Interestingly, in our patient, we were able to identify both fragments of HA: the filamentous particles and the spherical particles of dextranomer microspheres within the infiltrate, these last giving a characteristic and recognizable appearance to the histopathological picture.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biocompatible Materials - administration & dosage Biocompatible Materials - adverse effects
- Biopsy -
- Cosmetics - administration & dosage Cosmetics - adverse effects
- Face -
- Female -
- Granuloma, Foreign-Body - pathology
- Humans -
- Injections, Intradermal -
- Skin Aging -
- Find related publications in this database (Keywords)
- filler
- foreign body granuloma
- Matridex