Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Leis, HJ; Hohenester, E; Gleispach, H; Malle, E; Mayer, B.
Measurement of prostaglandins, thromboxanes and hydroxy fatty acids by stable isotope dilution gas chromatography/mass spectrometry.
Biomed Environ Mass Spectrom. 1987; 14(11):617-621
Doi: 10.1002/bms.1200141108
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- Führende Autor*innen der Med Uni Graz
- Leis Hans-Joerg
- Co-Autor*innen der Med Uni Graz
- Malle Ernst
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- Abstract:
- A method for measurement of PGF2 alpha, PGE1, PGE2, 6-keto-PGF1 alpha, TXB2, 2,3-dinor-TXB2 as well as 5-, 8-, 9-, 11-, 12-, 15-HETE and HHT, utilizing negative ion chemical ionization GC/MS is presented. A highly efficient separation and purification procedure prior to the derivatization sequence allows quantification of the arachidonic acid metabolites described in two GC/MS runs. The detection limit was in the femtomole range. Application of the method to the quantitative profiling of arachidonic acid metabolites in various tissues and incubation media is demonstrated.
- Find related publications in this database (using NLM MeSH Indexing)
- Gas Chromatography-Mass Spectrometry - methods
- Hydroxy Acids - analysis
- Hydroxyeicosatetraenoic Acids - analysis
- Isotope Labeling - analysis
- Oxygen Isotopes - analysis
- Prostaglandins - analysis
- Thromboxanes - analysis