Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reich, O; Pickel, H; Pürstner, P.
Exfoliative cytology of invasive neuroendocrine small cell carcinoma in a cervical cytologic smear. A case report.
Acta Cytol. 1996; 40(5):980-984
Doi: 10.1159/000334013
(- Case Report)
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Reich Olaf
- Co-Autor*innen der Med Uni Graz
- Pürstner Peter
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- Abstract:
- BACKGROUND: Neuroendocrine small cell carcinoma of the cervix (NSC) is cytologically identical to its counterparts at other sites, such as the lung, and can be suspected on a cervical cytologic smear. It has to be distinguished from poorly differentiated nonkeratinizing squamous small cell carcinoma, adenocarcinoma with carcinoid features, embryonal neuroblastoma, embryonal rhabdomyosarcoma, stromal sarcoma and non-Hodgkin's lymphoma. CASE: An 18-year-old woman had invasive NSC. Exfoliative cytology of the cervix showed tumor cells, single or in small clusters and files, with darkly staining nuclei. The chromatin pattern was coarse, with small, prominent chromocenters, and the nuclei were often invisible. The cytoplasm was so reduced as to be barely discernible. Mutual molding of adjacent nuclei was frequent. Immunohistochemistry showed positive staining for pancytokeratin and neuron-specific enolase. Flow cytometry showed aneuploidy, with a DNA index of 1.93. CONCLUSION: The cytologic appearance of NSC in a cervical cytologic smear is characteristic. The diagnosis, nevertheless, has to be proven by the identification of neuroendocrine differentiation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Carcinoma, Neuroendocrine - genetics
- Carcinoma, Small Cell - genetics
- DNA, Neoplasm - analysis
- Female - analysis
- Humans - analysis
- Neoplasm Invasiveness - analysis
- Uterine Cervical Neoplasms - genetics
- Vaginal Smears - genetics
- Find related publications in this database (Keywords)
- Carcinoma
- Neuroendocrine
- Carcinoma
- Small Cell
- Cervical Smears
- Cervix Neoplasms