Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Barthó, L; Pethö, G; Antal, A; Holzer, P; Szolcsányi, J.
Two types of relaxation due to capsaicin in the guinea pig isolated ileum.
NEUROSCI LETT 1987 81: 146-150.
Doi: 10.1016/0304-3940(87)90355-7
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Holzer Peter
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The relaxant effect of capsaicin was investigated on isolated segments of guinea pig ileum precontracted by histamine. Two types of relaxation could be distinguished. Low concentrations of capsaicin (0.033-3.3 microM) caused partial relaxation (type I) which was prevented by in vitro desensitization to capsaicin or by extrinsic denervation and reduced by tachyphylaxis to calcitonin gene-related peptide. At higher concentrations (10-100 microM) capsaicin caused relaxation (type II) to the baseline; this effect was insensitive to capsaicin desensitization or extrinsic denervation. Neither type of relaxation was inhibited by tetrodotoxin or by alpha- and beta-adrenoceptor antagonists. We suggest that type I relaxation results from a specific effect of capsaicin on extrinsic sensory neurones of the gut while type II represents a non-specific smooth muscle depressant effect. Intrinsic enteric neurones are not involved in these effects.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Atropine - pharmacology
- Capsaicin - pharmacology
- Comparative Study - pharmacology
- Guinea Pigs - pharmacology
- Histamine - pharmacology
- Ileum - drug effects
- In Vitro - drug effects
- Muscle Contraction - drug effects
- Muscle Relaxation - drug effects
- Muscle, Smooth - physiology
- Phentolamine - pharmacology
- Propranolol - pharmacology
- Research Support, Non-U.S. Gov't - pharmacology
- Tetrodotoxin - pharmacology