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Deutsch, J; Fueger, GF; Klos, I; Nicoletti, R.
Value of cholescintigraphy in the differential diagnosis of direct hyperbilirubinemia in infancy
WIEN KLIN WOCHENSCHR. 1987; 99: 629-636.
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Leading authors Med Uni Graz: Deutsch Johann
Co-authors Med Uni Graz: Nicoletti Rudolf
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Abstract:: Cholescintigraphy using 99mTc-diethyl-, 99mTc-diisopropyl-, 99mTc-iodo-diethyl- and 99mTc-bro-motrimethyl-IDA was performed in 22 newborns and infants with direct hyperbilirubinaemia. Retrospective evaluation of 99mTc-diethyl- and 99mTc-diisopropyl-IDA (n = 18) showed an efficiency of 66% in the differentiation between extrahepatic biliary atresia and neonatal intrahepatic diseases if the hepatocyte-clearance index and transit time were taken into consideration; the sensitivity of detecting extrahepatic biliary atresia was 100%. Cholestyramine treatment (n = 9) did not increase the efficiency of the test. Efficiency was markedly reduced when the serum direct bilirubin level was above 5.5 mg/dl (94 mumol/l). The gall bladder was not visualized in 13 out of 18 examinations. The prospective and retrospective analysis of 99mTc-iodo-diethyl- and 99mTc-bromo-trimethyl-IDA revealed intrahepatic disease in all 6 infants with serum values up to 12.6 mg/dl (216 mumol/l) direct bilirubin; the gall bladder was not visualized in 4 out of 7 examinations.
Find related publications in this database (using NLM MeSH Indexing): Biliary Atresia - radionuclide imaging; Comparative Study - radionuclide imaging; Diagnosis, Differential - radionuclide imaging; English Abstract - radionuclide imaging; Female - radionuclide imaging; Hepatitis - radionuclide imaging; Humans - radionuclide imaging; Hyperbilirubinemia - radionuclide imaging; Infant - radionuclide imaging; Infant, Newborn - radionuclide imaging; Jaundice, Neonatal - radionuclide imaging; Male - radionuclide imaging; Technetium - diagnostic use