Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
McMullen, JR; Shioi, T; Huang, WY; Zhang, L; Tarnavski, O; Bisping, E; Schinke, M; Kong, S; Sherwood, MC; Brown, J; Riggi, L; Kang, PM; Izumo, S.
The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway.
J Biol Chem. 2004; 279(6):4782-4793
Doi: 10.1074/jbc.M310405200
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- Co-Autor*innen der Med Uni Graz
- Bisping Egbert Hubertus
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- Abstract:
- Insulin-like growth factor 1 (IGF1) was considered a potential candidate for the treatment of heart failure. However, some animal studies and clinical trials have questioned whether elevating IGF1 chronically is beneficial. Secondary effects of increased serum IGF1 levels on other tissues may explain these unfavorable results. The aim of the current study was to examine the role of IGF1 in cardiac myocytes in the absence of secondary effects, and to elucidate downstream signaling pathways and transcriptional regulatory effects of the IGF1 receptor (IGF1R). Transgenic mice overexpressing IGF1R in the heart displayed cardiac hypertrophy, which was the result of an increase in myocyte size, and there was no evidence of histopathology. IGF1R transgenics also displayed enhanced systolic function at 3 months of age, and this was maintained at 12-16 months of age. The phosphoinositide 3-kinase (PI3K)-Akt-p70S6K1 pathway was significantly activated in hearts from IGF1R transgenics. Cardiac hypertrophy induced by overexpression of IGF1R was completely blocked by a dominant negative PI3K(p110alpha) mutant, suggesting IGF1R promotes compensated cardiac hypertrophy in a PI3K(p110alpha)-dependent manner. This study suggests that targeting the cardiac IGF1R-PI3K(p110alpha) pathway could be a potential therapeutic strategy for the treatment of heart failure.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Base Sequence -
- Cardiomegaly - etiology
- DNA, Complementary - genetics
- Heart - growth and development Heart - physiology
- Humans -
- Mice -
- Mice, Knockout -
- Mice, Transgenic -
- Phosphatidylinositol 3-Kinases - deficiency Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - physiology
- Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - physiology
- Recombinant Proteins - genetics Recombinant Proteins - metabolism
- Signal Transduction -
- Systole -