Medizinische Universität Graz - Research portal
Selected Publication:
Habermann, W; Eherer, A; Lindbichler, F; Raith, J; Friedrich, G.
Ex juvantibus approach for chronic posterior laryngitis: results of short-term pantoprazole therapy.
J Laryngol Otol. 1999; 113(8):734-739
Doi: 10.1017/S0022215100145050
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- Co-authors Med Uni Graz
- Eherer Andreas
- Friedrich Gerhard
- Lindbichler Franz
- Raith Johann
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- Abstract:
- The aim of this study was to investigate whether patients with chronic posterior laryngitis and symptoms of gastro-pharyngeal reflux benefit from a six-week therapy with pantoprozole. Twenty-nine out-patients with voice disorders (case history of at least two months) and simultaneous symptoms of gastro-pharyngeal reflux were recruited for this study. At the entry to the study a symptom questionnaire and a video-laryngo/stroboscopy were completed. The symptom questionnaire and the video-laryngo/stroboscopy were repeated after the six weeks of therapy with pantoprazole 40 mg once a day and again six weeks and three months after this follow-up, during which time the patient was without therapy. Hoarseness, globus pharyngeus, sore throat, heartburn, and coughing were the symptoms which showed a significant (p < 0.05) recovery at the follow-ups (mean of hoarseness index: 7.28 to 0.92; mean of globus pharyngeus index: 3.14 to 0.58; mean of heartburn index: 2.86 to 0.5; mean of cough index: 1.72 to 0.25; mean of throat soreness index: 1.72 to 0.15). Laryngoscopy scores of the posterior laryngeal region, the glottic and the supraglottic region showed statistically significant improvement (p < 0.05) after the treatment with pantoprazole. The therapeutic effect exceeded the drug administration until the last follow-up (after three months). The medication was tolerated without side-effects in all patients. A primary (ex juvantibus) therapy with proton pump inhibitors seems to be a therapeutic option for patients with long-lasting chronic inflammation of the larynx not responding to common therapy. In this case a six-week course of treatment has been shown to be sufficient.
- Find related publications in this database (using NLM MeSH Indexing)
- 2-Pyridinylmethylsulfinylbenzimidazoles -
- Adult -
- Anti-Ulcer Agents - therapeutic use
- Benzimidazoles - therapeutic use
- Chronic Disease -
- Female -
- Gastroesophageal Reflux - complications
- Humans -
- Laryngitis - drug therapy
- Male -
- Middle Aged -
- Omeprazole - analogs & derivatives
- Proton Pump Inhibitors -
- Proton Pumps - therapeutic use
- Questionnaires -
- Sulfoxides - therapeutic use
- Treatment Outcome -
- Voice Disorders - drug therapy
- Find related publications in this database (Keywords)
- Laryngitis
- Voice Disorders
- Gastroesophageal Reflux
- Proton Pump
- Drug Therapy