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Holzer, P; Beubler, E; Dirnhofer, R.
Barbiturate poisoning and gastrointestinal propulsion.
Arch Toxicol. 1987; 60(5):394-396 Doi: 10.1007/BF00295761
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Führende Autor*innen der Med Uni Graz: Holzer Peter
Co-Autor*innen der Med Uni Graz: Beubler Eckhard
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Abstract:: Anaesthetic doses of pentobarbitone (50 mg/kg) were found to inhibit gastric emptying and gastrointestinal transit in the rat. Gastric emptying was more profoundly suppressed than gastrointestinal transit. Phenobarbitone (150 mg/kg) had a similar effect. Since pentobarbitone and phenobarbitone also blocked the peristaltic reflex in the isolated small intestine of the guinea-pig, it would appear that the inhibitory effect of anaesthetic doses of barbiturates on gastrointestinal motility is mainly due to a direct action on the digestive tract. Together with the observation that considerable amounts of phenobarbitone were found in the stomach of an intoxicated patient 3 days after drug intake, these results might indicate that gastric lavage should also be considered in the treatment of protracted barbiturate poisoning.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Barbiturates - toxicity; Female - toxicity; Gastrointestinal Transit - drug effects; Guinea Pigs - drug effects; Intestine, Small - drug effects; Male - drug effects; Pentobarbital - toxicity; Peristalsis - drug effects; Phenobarbital - toxicity; Rats - toxicity; Rats, Inbred Strains - toxicity