Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fröhlich, E; Fink, I; Wahl, R.
Is transketolase like 1 a target for the treatment of differentiated thyroid carcinoma? A study on thyroid cancer cell lines.
Invest New Drugs. 2009; 27(4): 297-303.
Doi: 10.1007/s10637-008-9174-8
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Fröhlich Eleonore
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- Abstract:
- Radioactive iodine-refractory [(18)F] fluorodeoxy-glucose-positron emission tomography-positive thyroid carcinomas represent especially aggressive tumors. Targeting glucose metabolism by the transketolase isoenzyme transketolase like 1 (TKTL-1) which is over-expressed in various neoplasms, may be effective. The correlation of TKTL-1 expression and the response to oxythiamine as the currently best-characterized inhibitor of transketolases was studied in differentiated thyroid cancer cell lines. We determined TKTL-1 expression, proliferation, glucose uptake and GLUT-1 expression in non-treated thyroid cells and recorded the effect of oxythiamine on iodide uptake and on thymidine uptake. TKTL 1 was highest expressed in cell lines derived from more invasive tumors but the expression level was not strongly correlated to proliferation rate, to GLUT-1 expression or to the response to oxythiamine. Oxythiamine showed only a weak effect in the TKTL-1 expressing cell lines. Over-expression of TKTL-1 is not an indicator for responsiveness to oxythiamine. More specific inhibitors should be tested.
- Find related publications in this database (using NLM MeSH Indexing)
- Antimetabolites - pharmacology
- Cell Line, Tumor -
- Cell Proliferation - drug effects
- Drug Delivery Systems -
- Gene Expression Regulation, Neoplastic - drug effects
- Glucose - metabolism
- Glucose Transporter Type 1 - drug effects
- Humans -
- Iodides - metabolism
- Oxythiamine - pharmacology
- Thymidine - metabolism
- Thyroid Neoplasms - drug therapy
- Transketolase - antagonists and inhibitors
- Find related publications in this database (Keywords)
- Thyroid carcinoma
- Transketolase like 1
- Glucose metabolism
- Glucose transporter
- Oxythiamine