Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Maegele, M; Sauerland, S; Bouillon, B; Schäfer, U; Trübel, H; Riess, P; Neugebauer, EA.
Differential immunoresponses following experimental traumatic brain injury, bone fracture and two-hit-combined neurotrauma.
Inflamm Res. 2007; 56(8):318-323
Doi: 10.1007/s00011-007-6141-3
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- Co-authors Med Uni Graz
- Schäfer Ute
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- Abstract:
- OBJECTIVE AND DESIGN: Cytokine-mediated immunoresponses are consequences of isolated traumatic brain injury (TBI) and muskuloskeletal trauma but little is known when both impacts occur simulanteously in combined neurotrauma (CNT), i. e. TBI + muskuloskeletal trauma (bone fracture). MATERIALS AND METHODS: A "two-hit"-experimental model of CNT (TBI + tibia fracture) was used to investigate circulating cytokine interleukin-1-beta, -6, -10 and sTNF-R1 concentrations following peripheral bone fracture only, TBI only and CNT. Blood samples were drawn at 30 min, 6 h, 24 h, 48 h, and 7 days following trauma and circulating cytokine concentrations were determined via immunoassay. RESULTS: Circulating cytokines were increased after trauma (p <0.001 vs. controls), but peaked at different time points. sTNF R1 peaked first at 30 min, followed by IL-6 at 6 h after trauma. IL-10 levels were highest at 24 h, and those for IL-1beta at 48 h after trauma. Circulating IL-6 and IL-10 levels were highest in CNT at 8/10 time points studied (p <0.001). CONCLUSION: Circulating cytokine IL-1-beta, -6, -10 and sTNF-R1 concentrations are increased after trauma (TBI, fracture and CNT) but peak at different time points. Pronounced IL-6 and IL-10 responses after CNT may contribute to the increased susceptibility for complications in CNT versus monotrauma.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Brain Injuries - immunology
- Interleukin-10 - blood
- Interleukin-6 - blood
- Male - blood
- Rats - blood
- Rats, Sprague-Dawley - blood
- Receptors, Tumor Necrosis Factor, Type I - blood
- Tibial Fractures - immunology
- Whole-Body Irradiation - immunology
- Find related publications in this database (Keywords)
- cytokines
- traumatic brain injury
- tibia fracture
- combined neurotrauma
- inflammatory response