Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmitto, JD; Doerge, H; Post, H; Coutibaly, M; Sellin, C; Popov, AF; Sossalla, S; Schoendube, FA.
Progressive right ventricular failure is not explained by myocardial ischemia in a pig model of right ventricular pressure overload.
EUR J CARDIO-THORAC SURG. 2009; 35(2): 229-234.
Doi: 10.1016/j.ejcts.2008.09.010
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- Co-Autor*innen der Med Uni Graz
- Post Heiner
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- Abstract:
- Background: Current concepts of acute pulmonary embolism suggest that right ventricular (RV) dilatation and failure are the consequence of pressure overload-induced RV hypoperfusion and ischemia. Methods: Sixteen human-sized hybrid pigs were instrumented for the measurement of RV and aortic pressure, aortic and right coronary artery blood flow (RCA BF), RV oxygen consumption (RV MVO2) and RV free wait segment length. The pulmonary artery was constricted (PAC) to increase RV peak pressure acutely 2.5-fotd (from 27 +/- 2 to 64 +/- 3 mmHg, n = 9), and the constriction was maintained for 6 h. Results: At 10 min after PAC, a RV work index (RVWI, RV pressure-segment length loops) was increased 2.3-fold, indicating an initial RV adaptation to increased afterload. At 1 h, 3 h and 6 h after PAC, however, RVWI decreased progressively towards control levels, while RCA BF and RV MVO2 continued to increase. The arterial-coronary venous pH difference did not increase throughout the protocol. Arterial troponin T concentration increased from 0.08 +/- 0.03 to 0.80 +/- 0.20 ng/ml at 6 h after PAC. None of the parameters changed in control animals (n = 7). Conclusion: We conclude that in our model RV failure during PAC develops in spite of increased coronary blood flow and MVO2. Thus, mechanisms different from ischemia may contribute to progressive RV failure after pulmonary embolism. (C) 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Coronary Circulation - physiology
- Disease Models, Animal -
- Disease Progression -
- Female -
- Heart Failure - blood
- Hemodynamics -
- Hydrogen-Ion Concentration -
- Male -
- Myocardial Ischemia - blood
- Oxygen Consumption - physiology
- Pulmonary Embolism - blood
- Sus scrofa -
- Troponin T - blood
- Ventricular Dysfunction, Right - blood
- Find related publications in this database (Keywords)
- Right ventricular function
- Pressure overload
- Ischemia
- Pulmonary embolism