Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Korsatko, W; Sadjak, A; Gall, P; Supanz, S.
Development of combined inulin/p-aminohippuric acid (PAH) slow release implantation tablets for clearance determination in awake rats
PHARMAZIE. 1987; 42(5): 324-327.
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- Co-Autor*innen der Med Uni Graz
- Sadjak Anton
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- Abstract:
- A new method has been developed for the simultaneous measurement of Inulin and PAH clearance in small laboratory animals (rats). An implantable Inulin/p-aminohippuric-acid matrix-retard tablet based on Eudragit was tested with the purpose to estimate renal clearances. Sufficiently high serum and urine levels of both substances can thus be maintained up to 12-48 hours. The advantage of the method is that it can be used for renal clearance tests in small conscious animals, able to move freely within their cages without serious handling stress.
- Find related publications in this database (using NLM MeSH Indexing)
- Aminohippuric Acids - diagnostic use
- Animals - diagnostic use
- Delayed-Action Preparations - diagnostic use
- English Abstract - diagnostic use
- Inulin - diagnostic use
- Kidney - metabolism
- Metabolic Clearance Rate - metabolism
- Rats - metabolism
- p-Aminohippuric Acid - diagnostic use