Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sirvent, A; Claudel, T; Martin, G; Brozek, J; Kosykh, V; Darteil, R; Hum, DW; Fruchart, JC; Staels, B.
The farnesoid X receptor induces very low density lipoprotein receptor gene expression.
FEBS Lett. 2004; 566(1-3): 173-177.
Doi: 10.1016/j.febslet.2004.04.026
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Claudel Thierry
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- Abstract:
- The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs). In response to ligand-binding, FXR regulates many genes involved in BA, lipid, and lipoprotein metabolism. To identify new FXR target genes, microarray technology was used to profile total RNA extracted from HepG2 cells treated with the natural FXR agonist chenodeoxycholic acid (CDCA). Interestingly, a significant increase of transcript level of the very low density lipoprotein receptor (VLDLR) was observed. Our data, resulting from selective FXR activation, FXR RNA silencing and FXR-deficient mice, clearly demonstrate that BAs up-regulate VLDLR transcript levels via a FXR-dependent mechanism in vitro in human and in vivo in mouse liver cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bile Acids and Salts - pharmacology
- Cell Line, Tumor - pharmacology
- Chenodeoxycholic Acid - pharmacology
- DNA-Binding Proteins - agonists
- Hepatocytes - metabolism
- Humans - metabolism
- Isoxazoles - pharmacology
- Liver - metabolism
- Male - metabolism
- Mice - metabolism
- Mice, Inbred C57BL - metabolism
- Mice, Knockout - metabolism
- RNA, Small Interfering - pharmacology
- Receptors, Cytoplasmic and Nuclear - pharmacology
- Receptors, LDL - biosynthesis
- Time Factors - biosynthesis
- Transcription Factors - agonists
- Transcription, Genetic - drug effects
- Transfection - drug effects
- Up-Regulation - drug effects
- Find related publications in this database (Keywords)
- farnesoid X receptor
- microarray analysis
- VLDL receptor
- small interfering RNA