Medizinische Universität Graz - Research portal
Selected Publication:
Sinskı, M; Donnerer, J.
Evidence for a neurotransmitter role of glutamate in guinea pig myenteric plexus neurons.
Neurosci Lett. 1998; 258(2):109-112
Doi: 10.1016/S0304-3940(98)00866-0
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Donnerer Josef
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Longitudinal muscle-myenteric plexus strips of the guinea pig ileum were used to investigate a possible transmitter role of glutamate (Glu) in the enteric nervous system. Glu was released from this nerve muscle preparation by high K(+)-depolarization in a Ca2(+)-dependent manner, by electrical field stimulation and by the ganglionic stimulant dimethylphenylpiperazinium which indicates its neural origin. Contractions of the longitudinal muscle evoked by electrical stimulation of the myenteric nerves or by Glu, were significantly reduced by the N-methyl-D-aspartate (NMDA)-receptor antagonist FR115427 (9 and 18 microM), whereas contractions induced by histamine were unaffected. The results show that the amino acid Glu is likely to play an excitatory neurotransmitter role via NMDA receptors in the myenteric plexus of the guinea pig.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Chromatography, High Pressure Liquid -
- Dimethylphenylpiperazinium Iodide - pharmacology
- Electric Stimulation -
- Excitatory Amino Acid Antagonists - pharmacology
- Female -
- Ganglionic Stimulants - pharmacology
- Glutamic Acid - metabolism
- Guinea Pigs -
- Histamine - pharmacology
- Ileum - drug effects
- Isoquinolines - pharmacology
- Male -
- Muscle Contraction - drug effects
- Muscle, Smooth - drug effects
- Myenteric Plexus - drug effects
- Neurons - drug effects
- Neurotransmitter Agents - metabolism
- Potassium - pharmacology
- Sodium Glutamate - pharmacology
- Tetrahydroisoquinolines -
- Tetrodotoxin - pharmacology
- Find related publications in this database (Keywords)
- Enteric Nervous System
- Glutamate Release
- Smooth Muscle Contractions
- N-Methyl-D-Aspartate Receptor