Medizinische Universität Graz - Research portal
Selected Publication:
Lindner, W; Rath, M; Stoschitzky, K; Semmelrock, HJ.
Pharmacokinetic data of propranolol enantiomers in a comparative human study with (S)- and (R,S)-propranolol.
Chirality. 1989; 1(1):10-13
Doi: 10.1002/chir.530010105
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- Co-authors Med Uni Graz
- Semmelrock Hans-Jürgen
- Stoschitzky Kurt
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- Abstract:
- The pharmacokinetics of (S)-propranolol were compared after the oral administration of a 40 mg dose of the pure enantiomer and an 80 mg dose of a racemic mixture of (R,S)-propranolol. The results of this study indicate that the bioavailability of (S)-propranolol, as expressed by the mean area under the concentration-time curve (AUC) and maximum serum concentration, is lower after 40 mg of the optically pure drug than after the racemic drug.
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- Adult -
- Biological Availability -
- Female -
- Half-Life -
- Humans -
- Male -
- Propranolol - pharmacokinetics
- Stereoisomerism - pharmacokinetics