Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kostner, GM.
Lipoprotein receptors and atherosclerosis.
Biochem Soc Trans. 1989; 17(4):639-641
Doi: 10.1042/bst0170639
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Kostner Gerhard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The whole lipoprotein spectrum of human plasma may be divided into atherosclerotic and anti-atherosclerotic lipoproteins. To the first class belong apolipoprotein (apo) B and some apoE-containing lipoproteins of the very-low-density (VLDL), intermediate-density (IDL) and low-density (LDL) lipoprotein fractions. Anti-atherosclerotic lipoproteins are apoA-containing high-density lipoproteins (HDL). Circulating plasma lipoproteins are catabolized mainly by specific cell surface receptors (R) which react with apoB and apoE (B/E-R), for apoE (E-R) or for apoA (HDL-R). Whereas the B/E-R and E-R are responsible for the cellular uptake of lipoproteins and their lipid load by various organs, HDL-R are thought to promote lipid (cholesterol) efflux. There is an additional class of lipoprotein receptors, the so called scavenger-R which are responsible for the removal of altered or degraded lipoproteins for the circulation. Under normal physiological conditions, the concerted action of these receptors warrants efficient lipoprotein turnover and direction into target organs. Derangements of this system, however, may lead to the deposition and accumulation of atherogenic lipids, notably free cholesterol (FC) and cholesteryl esters (CE) in arterial tissue causing atherosclerosis and cardiac death.
- Find related publications in this database (using NLM MeSH Indexing)
- Apolipoproteins A - metabolism
- Apolipoproteins B - metabolism
- Apolipoproteins E - metabolism
- Arteriosclerosis - metabolism
- Carrier Proteins - metabolism
- Humans - metabolism
- Lipoproteins - metabolism
- Lipoproteins, HDL - metabolism
- Membrane Proteins - metabolism
- RNA-Binding Proteins - metabolism
- Receptors, Cell Surface - metabolism
- Receptors, Immunologic - metabolism
- Receptors, LDL - metabolism
- Receptors, Lipoprotein - metabolism
- Receptors, Scavenger - metabolism
- Scavenger Receptors, Class B - metabolism