Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Dohr, GA; Motter, W; Leitinger, S; Desoye, G; Urdl, W; Winter, R; Wilders-Truschnig, MM; Uchanska-Ziegler, B; Ziegler, A.
Lack of expression of HLA corrected class I and class II molecules on the human oocyte.
J Immunol. 1987; 138(11):3766-3770
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- Führende Autor*innen der Med Uni Graz
- Dohr Gottfried
- Co-Autor*innen der Med Uni Graz
- Desoye Gernot
- Truschnig-Wilders Martini
- Urdl Wolfgang
- Winter Raimund
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- Abstract:
- The expression of histocompatibility leukocyte antigen (HLA) class I and class II antigens on human oocytes was investigated by the indirect immunofluorescence assay using well-defined monoclonal antibodies. Oocytes were obtained from an in vitro fertilization program or were studied on frozen sections from human ovaries. Neither HLA class I, beta 2-microglobulin, nor HLA class II molecules were detected on cultured oocytes or frozen sections. The zona pellucida also lacked these antigens, but granulosa cells expressed HLA class I molecules. Our results also indicate the presence of certain types of class II molecules on granulosa cells. The present experiments demonstrate that the human oocyte belongs to those few cell types in the human body which are devoid of both types of HLA molecules.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies, Monoclonal - diagnostic use
- Cell Membrane - immunology
- Female -
- Fluorescent Antibody Technique -
- Granulosa Cells - immunology
- HLA Antigens - immunology
- HLA-D Antigens - immunology
- Humans -
- Oocytes - immunology
- Zona Pellucida - immunology