Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Barthó, L; Lembeck, F; Holzer, P.
Calcitonin gene-related peptide is a potent relaxant of intestinal muscle.
EUR J PHARMACOL. 1987; 135: 449-451.
Doi: 10.1016/0014-2999(87)90699-6
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Co-Autor*innen der Med Uni Graz
- Lembeck Fred
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The motor effects of calcitonin gene-related peptide (CGRP) on the guinea-pig ileum (GPI) longitudinal muscle were investigated. CGRP (0.1-100 nM) concentration dependently relaxed ilea precontracted with histamine and inhibited electrically induced cholinergic contractions. At higher concentrations (3-100 nM) CGRP also caused a slight contraction of non-stimulated ilea. Further pharmacological analysis of the CGRP-induced relaxation which seems to be the primary CGRP effect in the GPI, indicated that the effect was due to a direct action on the longitudinal muscle.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcitonin Gene-Related Peptide -
- Electric Stimulation -
- Guinea Pigs -
- Ileum - drug effects
- In Vitro - drug effects
- Muscle Relaxation - drug effects
- Muscle, Smooth - drug effects
- Neuropeptides - pharmacology
- Research Support, Non-U.S. Gov't - pharmacology