Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Maegele, M; Lippert-Gruener, M; Ester-Bode, T; Sauerland, S; Schäfer, U; Molcanyi, M; Molcany, M; Lefering, R; Bouillon, B; Neiss, WF; Angelov, DN; Klug, N; McIntosh, TK; Neugebauer, EA.
Reversal of neuromotor and cognitive dysfunction in an enriched environment combined with multimodal early onset stimulation after traumatic brain injury in rats.
J Neurotrauma. 2005; 22(7):772-782
Doi: 10.1089/neu.2005.22.772
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Molcanyi Marek
- Schäfer Ute
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- Abstract:
- This study was designed to investigate the additional benefits of a multimodal early onset stimulation (MEOS) paradigm when combined with enriched environment (EE) versus EE only and standard housing (SH) on the recovery after experimental traumatic brain injury (TBI). Male Sprague- Dawley rats were subjected to moderate lateral fluid percussion (LFP) brain injury (n = 40) or sham operation (n = 6). Thereafter, the injured and sham/EE + MEOS and EE only groups were placed into a complex EE consisting of tunnel-connected wide-bodied cages with various beddings, inclining platforms, and toys. Along with group living and environmental complexity, injured and sham/EE + MEOS animals were additionally exposed to a standardized paradigm of multimodal stimulation including auditory, visual, olfactory, and motor stimuli. In contrast, injured and sham/SH groups were housed individually without stimulation. A standardized composite neuroscore (NS) test was used to assess acute post-traumatic neuromotor deficits (24 h after injury) and recovery on days 7 and 15; recovery of cognitive function was assessed on days 11-15 using the Barnes maze. Neuromotor impairment was comparable in all injured animals at 24 h post-injury, but braininjured EE + MEOS rats performed significantly better than both brain-injured SH and EE groups when tested on post-injury days 7 and 15 (p = 0.004). Similarly, latencies to locate the hidden box under the Barnes maze platform were significantly shortened in EE + MEOS animals at day 15 (p = 0.003). These results indicate that the reversal of neuromotor and cognitive dysfunction after TBI can be substantially enhanced when MEOS is added to EE.
- Find related publications in this database (using NLM MeSH Indexing)
- Acoustic Stimulation - methods
- Animals -
- Brain Injuries - complications Brain Injuries - physiopathology Brain Injuries - therapy
- Cognition Disorders - etiology Cognition Disorders - physiopathology Cognition Disorders - therapy
- Disease Models, Animal -
- Environment Design -
- Male -
- Maze Learning - physiology
- Movement Disorders - etiology Movement Disorders - physiopathology Movement Disorders - therapy
- Odors -
- Photic Stimulation - methods
- Physical Conditioning, Animal - physiology
- Physical Stimulation - methods
- Physical Therapy Modalities -
- Rats -
- Rats, Sprague-Dawley -
- Recovery of Function - physiology
- Time Factors -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- cognitive
- enriched environment
- neuromotor
- rat
- recovery
- stimulation
- traumatic brain injury