Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Charalampaki, P; Hildebrandt, G; Schaeffer, HJ; Schönau, E; Klug, N.
Insulin-like growth factor binding protein-3 levels during early and late follow-up after surgery in acromegalic patients.
Exp Clin Endocrinol Diabetes. 1998; 106(2):130-134
Doi: 10.1055/s-0029-1211964
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- Charalampaki Patra
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- Abstract:
- Disease activity in acromegaly is accurately reflected by growth hormone (GH) concentration during oral glucose tolerance test (OGTT) and insulin-like growth factor-I (IGF-I) levels, representing an integrated index of GH activity. This prospective study was performed to evaluate whether plasma IGF binding protein 3 (IGFBP-3) might also reflect the hormonal disease activity in pituitary acromegaly after operative treatment during early and late follow-up. Twenty-two acromegalic patients were studied. Data were obtained pre-, intra- and post-operatively in 13 cases. In 9 patients the acromegalic activity was studied only after treatment. The hormonal assessment included repeated blood samples for estimation of IGF-I, IGFBP-3 and repeated OGTTs. In each case 100 sigma g octreotide (Sandostatin lambda, Sandoz, Basel) was injected to test the acute response of GH, IGF-I and IGFBP-3. Intraoperatively, GH levels were estimated to examine acutely the influence of tumour reduction on GH levels. Patients were considered cured when GH levels (GH60min) were less than 2 ng/ml during OGTT 4 weeks after surgery. The data outlined that in patients with normalized GH60min levels, normalized IGFBP-3 levels were noticed 4 weeks and 12 months post-operatively. In non-cured patients normalized IGFBP-3 concentrations were found in 11 out of 15 cases in the late post-treatment phase. In contrast only 1 of 7 cured patients had persistently elevated IGF-I levels within the first month post-operatively, whereas no case of the non-cured patients had IGF-I values in the normal range. Despite these observations a strong correlation of IGF-I and IGFBP-3 did not exist before one year post-operatively -- either in the cured or in the non-cured patients. Serum IGFBP-3 in patients with pituitary acromegaly does not provide a predictive value of appreciable magnitude concerning cure or non-cure from the disease- whether examined early or late in the post-operative period. Absolute levels of IGFBP-3 may thus cause misinterpretation concerning cure of acromegalics after surgery.
- Find related publications in this database (using NLM MeSH Indexing)
- Acromegaly - blood
- Adult - blood
- Aged - blood
- Female - blood
- Follow-Up Studies - blood
- Glucose Tolerance Test - blood
- Growth Hormone - blood
- Hormones - therapeutic use
- Humans - therapeutic use
- Insulin-Like Growth Factor Binding Protein 3 - blood
- Insulin-Like Growth Factor I - drug effects
- Male - drug effects
- Middle Aged - drug effects
- Octreotide - therapeutic use
- Postoperative Period - therapeutic use
- Prospective Studies - therapeutic use
- Time Factors - therapeutic use
- Find related publications in this database (Keywords)
- pituitary acromegaly
- insulin-like growth factor-I
- insulin-like growth factor binding protein-3
- late follow-up