Medizinische Universität Graz - Research portal
Selected Publication:
Schreibmayer, W; Hofer, E; Wolf, P; Lueger, A; Tritthart, HA.
Analysis of single channel currents with a microprocessor based device.
Z Naturforsch [C]. 1987; 42(3):173-177
Doi: 10.1515/znc-1987-0301
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Schreibmayer Wolfgang
- Co-authors Med Uni Graz
- Hofer Ernst
- Tritthart Helmut
- Wolf Peter
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- Abstract:
- Data evaluation of single channel currents obtained from artificial black lipid membranes and with the patch clamp method is an important part of every single channel study, but it is a time consuming part often exceeding the time for experimentation and recording by far. We describe here a microprocessor based device, which allows the experimentator to analyse in a simple way the distribution of current levels in a single channel trace (amplitude-histogram analysis of single channel currents) either online, or offline. Current levels are sampled at a constant frequency of 6 kHz and the relative frequencies of occurrence of these current levels are displayed as a histogram on the screen of an analog or digital storage oscilloscope. The data reducing algorithm of this analyser eliminates the requirement of large amounts of mass storage that normally is needed for digital amplitude-histogram analysis of single channel recordings. Examples of evaluation for both a voltage operated cation-channel and a blockage of a potassium channel by tetraethylammoniumchloride (TEA) are given.
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