Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Franz, MB; Andreas, M; Schiessl, B; Zeisler, H; Neubauer, A; Kastl, SP; Hess, G; Rhomberg, F; Zdunek, D; Maurer, G; Schlembach, D; Heinze, G; Szekeres, T; Gottsauner-Wolf, M.
NT-proBNP is increased in healthy pregnancies compared to non-pregnant controls.
Acta Obstet Gynecol Scand. 2009; 88(2):234-237
Doi: 10.1080/00016340802596025
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- Co-authors Med Uni Graz
- Andreas Martin
- Schlembach Dietmar
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- Abstract:
- Serum concentrations of the amino-terminal pro-B-type natriuretic peptide (NT-proBNP) may be used to monitor cardiac function during pregnancy but normal values are not established for this purpose. Therefore, we investigated NT-proBNP in normotensive healthy pregnancies compared to a non-pregnant control group. Serum NT-proBNP was measured in 94 normotensive, healthy pregnant women (32+/-6 years) every five weeks beginning from 12th gestational week (GW) in a longitudinal study and compared to a non-pregnant control group of 521 women (32+/-7 years). Pooled median serum NT-proBNP levels (25th; 75th percentile) were significantly higher in pregnant women compared to non-pregnant women (56 (33; 95) pg/ml vs. 38 (22; 62) pg/ml (p<0.001)). NT-proBNP increased during pregnancy to 73 (51; 124) pg/ml in the 11+6 to 15+6 GW (p<0.001). However, NT-proBNP levels from 23+0 GW towards term were comparable to non-pregnant controls. NT-proBNP is significantly elevated in healthy pregnancies until mid-pregnancy. As preeclampsia and gestational hypertension are associated with increased NT-proBNP, our results have to be considered in future diagnostic approaches using NT-proBNP for these pathologic conditions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Female -
- Humans -
- Natriuretic Peptide, Brain - blood
- Peptide Fragments - blood
- Pregnancy - blood
- Reference Values -
- Find related publications in this database (Keywords)
- NT-proBNP
- pregnancy
- preeclampsia
- heart failure