Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Burtscher, M; Haider, T; Domej, W; Linser, T; Gatterer, H; Faulhaber, M; Pocecco, E; Ehrenburg, I; Tkatchuk, E; Koch, R; Bernardi, L.
Intermittent hypoxia increases exercise tolerance in patients at risk for or with mild COPD.
Respir Physiol Neurobiol. 2009; 165(1):97-103
Doi: 10.1016/j.resp.2008.10.012
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Domej Wolfgang
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- Abstract:
- The effects of repeated short-term hypoxia on exercise tolerance in patients at risk for, or with mild COPD were investigated. Eighteen patients (10 males, 8 females; 33-72 years) were randomly assigned in a double-blind fashion to receive 15 sessions of intermittent hypoxia (FiO(2): 0.15-0.12) or normoxia within 3 weeks. Three weeks of intermittent hypoxia increased total haemoglobin mass (+4% vs. 0%, p<0.05), total exercise time (+9.7% vs. 0%, p<0.05) and the exercise time to the anaerobic threshold (+13% vs. -7.8%, p<0.05) compared to controls. Changes in the total exercise time were positively related to the changes in total haemoglobin mass (r=0.59, p<0.05) and changes in the time to the anaerobic threshold were positively related to the changes in the lung diffusion capacity for carbon monoxide (r=0.48, p<0.05). Intermittent hypoxia treatment may be a valuable addition to therapy designed to improve exercise tolerance in patients at risk for, or with mild COPD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Anaerobic Threshold - physiology
- Analysis of Variance -
- Carbon Monoxide - metabolism
- Double-Blind Method -
- Exercise - physiology
- Exercise Test -
- Exercise Tolerance - physiology
- Female -
- Hemoglobins - metabolism
- Humans -
- Hypoxia -
- Male -
- Middle Aged -
- Pulmonary Disease, Chronic Obstructive - physiopathology
- Risk Assessment -
- Time Factors -
- Find related publications in this database (Keywords)
- Intermittent hypoxia
- COPD
- Exercise tolerance
- Lung function
- Haemoglobin mass
- Lung diffusion capacity