Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Porta, S; Supanz, S; Gleispach, H; Rinner, I; Ertl, U.
Long-term adrenergic beta-action decreases and alpha-action enhances corticosterone levels in rats.
EXP PATHOL. 1987; 31(1): 59-61.
Doi: 10.1016/S0232-1513(87)80094-4
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- Führende Autor*innen der Med Uni Graz
- Porta Sepp
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- Abstract:
- A 20 h hyperadrenalinemia in rats was produced by subcutaneously implanted A-retard tablets with an output rate of 1.8 micrograms/min/250 g. This caused a moderate (6 h, 20 h) to expressed (12 h) rise in Corticosterone. Concomitant beta-blockade leads to equal (12 h, 20 h) or even more expressed (6 h) enhancement of plasma corticosterone, while A + alpha-blockade lowers those levels significantly against A or A + Prop treated animals. At 6 and 20 h they are even significantly lower than control values. We therefore conclude that enhanced alpha-adrenergic influence increases and beta-adrenergic influence decreases plasma Corticosterone levels in rats.
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