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Donnerer, J; Oka, K; Brossi, A; Rice, KC; Spector, S.
Presence and formation of codeine and morphine in the rat.
Proc Natl Acad Sci U S A. 1986; 83(12):4566-4567 Doi: 10.1073/pnas.83.12.4566 [OPEN ACCESS]
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Leading authors Med Uni Graz: Donnerer Josef
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Abstract:: Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats intravenously. These compounds, which are intermediates in the synthesis of morphine in Papaver somniferum, caused a marked increase in the codeine and morphine levels in rat tissues. This provides evidence for a biosynthetic pathway to morphine in mammalians.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Chromatography, High Pressure Liquid -; Codeine - biosynthesis; Male - biosynthesis; Morphine - biosynthesis; Radioimmunoassay - biosynthesis; Rats - biosynthesis; Tissue Distribution - biosynthesis