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Selected Publication:

Cardinale, GJ; Donnerer, J; Finck, AD; Kantrowitz, JD; Oka, K; Spector, S.
Morphine and codeine are endogenous components of human cerebrospinal fluid.
Life Sci. 1987; 40(3):301-306 Doi: 10.1016/0024-3205(87)90347-X
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Co-authors Med Uni Graz
Donnerer Josef
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Abstract:
We have examined cerebrospinal fluid (CSF) from twelve patients who were not on any medication and found them to contain both morphine and codeine in concentrations of 2 to 339 fmol/ml. These are comparable to the concentration of opioid peptides in spinal fluid. Both morphine and codeine are present mainly in conjugated form from which the free alkaloids can be released by acid hydrolysis.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Antibodies, Monoclonal - diagnostic use
Child - diagnostic use
Child, Preschool - diagnostic use
Codeine - cerebrospinal fluid
Female - cerebrospinal fluid
Humans - cerebrospinal fluid
Male - cerebrospinal fluid
Middle Aged - cerebrospinal fluid
Morphine - cerebrospinal fluid

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