Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rotheneder, M; Kostner, GM.
Cholesterol esterification in mouse peritoneal macrophages in the presence of pathological human plasma lipoproteins.
Biol Chem Hoppe Seyler. 1986; 367(12):1219-1222
Doi: 10.1515/bchm3.1986.367.2.1219
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- Führende Autor*innen der Med Uni Graz
- Dieber-Rotheneder Martina
- Co-Autor*innen der Med Uni Graz
- Kostner Gerhard
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- Abstract:
- Mouse peritoneal macrophages were incubated with abnormal lipoproteins (LP-X, HDL-E, VLDL-p, IDl-p and LDL-p) from a patient with secondary deficiency in phosphatidylcholine-sterol acyltransferase, or with phosphatidylcholine/cholesterol liposomes, and the stimulation of cholesteryl ester formation was studied. Acetylated low density lipoproteins served as a control. It was found that macrophages incubated with LP-X, the other pathological lipoproteins or with liposomes did not show an enhanced cholesterol esterification. Also HDL-E had no effect despite of its high apoE content and the fact that apoE has been postulated to be the agonist in beta-VLDL binding to macrophages.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cholesterol Esters - biosynthesis
- Female -
- Lipoprotein-X - blood Lipoprotein-X - pharmacology
- Lipoproteins - blood Lipoproteins - pharmacology
- Lipoproteins, HDL - blood Lipoproteins, HDL - pharmacology
- Liposomes -
- Macrophages - drug effects Macrophages - metabolism
- Male -
- Mice -