Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Chandak, PG; Gaikwad, AB; Tikoo, K.
Gallotannin ameliorates the development of streptozotocin-induced diabetic nephropathy by preventing the activation of PARP.
Phytother Res. 2009; 23(1):72-77
Doi: 10.1002/ptr.2559
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Chandak Prakash Gopal Das
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- Abstract:
- Poly(ADP-ribose) polymerase (PARP) is known to be activated under conditions of oxidative stress and/or radiation exposure. The role of this enzyme has been well demonstrated in the streptozotocin (STZ) induced model of diabetes. Inhibition of PARP by specific inhibitors is known to prevent the development of STZ induced diabetic nephropathy by reduction in oxidative stress induced apoptosis. This study shows for the first time the role of poly(ADP-ribose) glycohydrolase (PARG) inhibitors as an alternative approach for inhibition of PARP. Gallotannin (20 mg/kg/day, i.p.) treatment for 4 weeks led to a significant reduction in the levels of plasma creatinine which is a well known marker for diabetic nephropathy. Treatment with gallotannin resulted in protection up to a certain level of glomerular damage, suggesting compensatory glomerular hypertrophy. As a PARG inhibitor gallotannin treatment also showed protection in PARP cleavage which is a hallmark for apoptotic cell death signifying the protective role of gallotannin in cell death signaling.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Apoptosis - drug effects
- Creatinine - blood
- Diabetes Mellitus, Experimental - prevention and control
- Diabetic Nephropathies - prevention and control
- Enzyme Inhibitors - pharmacology
- Hydrolyzable Tannins - pharmacology
- Kidney - physiopathology
- Male -
- Poly(ADP-ribose) Polymerases - antagonists and inhibitors Poly(ADP-ribose) Polymerases - metabolism
- Rats -
- Rats, Sprague-Dawley -
- Find related publications in this database (Keywords)
- diabetic nephropathy
- PARG inhibitor
- gallotannin
- PARP