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DITTRICH, P; OSTROWSKI, J; BEUBLER, E; SCHRAVEN, E; KUKOVETZ, W.
DETERMINATION BY HPLC OF TROXERUTIN IN PLASMA AND URINE FOLLOWING ORAL-ADMINISTRATION TO MAN
ARZNEIM-FORSCH-DRUG RES. 1985; 35-1(4): 765-767.
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Co-authors Med Uni Graz: Beubler Eckhard
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Abstract:: A high-performance liquid chromatographic method (HPLC) is described for the analysis of 3',4',7-tri-O-(beta-hydroxy-ethyl)-rutoside (troxerutin) in human plasma and urine. After separation of interfering substances on XAD-2 trihydroxyethylrutoside is converted to tetrahydroxyethylrutoside by 2-chlorethanol in alkaline medium. After HPLC-separation tetrahydroxyethylrutoside is quantified by fluorescence detection. The pharmacokinetics of troxerutin were measured in plasma after oral administration to man. The relative bioavailability of the drug from Venelbin was 97.8 +/- 37.1% compared to an aqueous standard solution.
Find related publications in this database (using NLM MeSH Indexing): Anticoagulants - analysis; Chromatography, High Pressure Liquid - analysis; Humans - analysis; Hydroxyethylrutoside - analogs and derivatives; Rutin - analogs and derivatives